However, assessing chromium deficiency is difficult. Blood chemistries revealed no significant adverse effects from the ingestion of 600 microg of niacin-bound chromium daily over 2 months. The major role for chromium in weight loss is to correct insulin resistance caused by chromium deficiency. 7 When the study results were combined, the study participants lost about 2 pounds more than those receiving a placebo. Once chromium was given at these dose levels, there was a 'carry-over' effect. A Cochrane review analyzed nine randomized controlled trials looking at chromium picolinate supplementation on weight loss, with a follow-up of up to six months. Niacin-bound chromium given to modestly dieting-exercising African-American women caused a significant loss of fat and sparing of muscle compared to placebo. Blood chemistries were not affected by intake of chromium for 2 months. In contrast to the previous findings, there was a significantly greater loss of fat in the placebo compared to the verum period in the second group of eight women who received chromium first (group 2). loss was essentially the same, but fat loss was significantly greater and non-fat body mass loss significantly less with chromium intake. In the first group of 10 women receiving niacin-bound chromium after the placebo period (group 1), b.w. For the placebo group, the calculated absorption of chromium at study weeks 7 and 13 remained similar to baseline (0.240.59). Fat and nonfat body masses were estimated using bioelectrical impedance (electrolipography). According to a systematic review of 14 studies, glucomannan can lower ( 10 ): Total cholesterol by 19. Chromium is an essential trace element and nutritional supplement that has garnered interest for use as a weight loss aid. Body weights (b.w.) and blood chemistries were measured by routine clinical methodology. In addition to promoting weight loss, glucomannan may improve some heart disease risk factors. One-half received placebo first (group 1), the other half received chromium first (group 2). Control and verum periods were each 2 months in duration. They received placebo three times a day (t.i.d.) during the control period and niacin-bound chromium, 200 microg t.i.d., during the verum period. Twenty overweight African-American women, engaged in a modest diet-exercise regimen, participated in a randomized, double-blinded, placebo-controlled, crossover study. Overall, the meta-analysis found that chromium picolinate produced slim weight loss results (1.1kg) after 12-16 weeks in these people. However, many clinical studies failed to demonstrate improvements in glucose metabolism, weight loss, or muscle mass. This pilot study was designed to determine whether 600 microg niacin-bound chromium ingested daily over 2 months by African-American women undergoing a modest dietary and exercise regimen influences weight loss and body composition. The dosage of chromium for weight loss used in these studies was up to 1000mcg per day.
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